SRGN and breast cancer: In MCF7 breast cancer cells, overexpression of the full-length SRGN (158 amino acids) promoted cell proliferation and migration, however, overexpression of a truncated mutant (containing the N-terminal 111 amino acids) in which the GAG attachment sites were removed failed to promote cell proliferation and migration [22], suggesting a potential role of GAG modification in SRGN-mediated functions.