PTEN and melanoma: Alternatively, a melanoma model YUMMER1.7 has been derived through irradiation of the genetically engineered mouse melanoma YUMM1.7 cell line, which harbors three driver mutations: BrafV600E, Pten−/− and Cdkn2a−/−, and has been reported to have increased T cell infiltration and response to immune check point inhibition [33] .