This includes ALKF1174 and ALKR1275 mutations and MYCN amplifications in primary neuroblastomas [29, 56, 63], the BRAFV600E mutation in Langerhans cell histiocytosis [3], and EWSR1 translocations in Ewing sarcoma [20], to name a few. Here, EWSR1 is linked to Langerhans cell histiocytosis.