This finding - the effects of NUCB2/Nesfatin-1 on energy balance, obesity, glucose metabolism and this being related to delayed puberty of lower NUCB2/Nesfatin-1 - showed that NUCB2/Nesfatin-1 in normal and pathological conditions may be important in the functioning of the ovaries and in reproduction (1, 3, 7, 8). Here, NUCB2 is linked to obesity due to melanocortin 4 receptor deficiency.