Our data with respect to NUCB2/Nesfatin-1 levels are similar to previous studies in which blood NUCB2/Nesfatin-1 levels were evaluated in PCOS patients and in the other cases of insulin resistance like type 2 diabetes, gestational diabetes or morbid obesity (1, 3, 10, 15–17). This evidence concerns the gene NUCB2 and type 2 diabetes mellitus.