The results showed that TP53 was associated with thrombocytopenia (r= -0.25, P=0.02), complex karyotype (r=0.38, P<0.001) and higher IPSS/IPSS-R risk level (r=0.35, P=0.001, r=0.33, P=0.002). The gene discussed is TP53; the disease is Thrombocytopenia.