As a competitive endogenous RNA(ceRNA), PVT1 suppressed MMP9 expression via competitively binding miR-200a and miR-200b to destroy the reconstruction ability of respiratory tract and lung tissues to induce NSCLC, suggesting that the lncRNA-PVT1-MMP9 axis may be a potential target for NCSLC metastasis76. The gene discussed is MMP9; the disease is non-small cell lung carcinoma.