PVT1 and cancer: Second, the PVT1 locus encodes a range of non-coding RNAs as well as generates a cluster of six annotated microRNAs (namely, miR-1204, miR-1205, miR-126, miR-1207-5p, miR-1207-3p and miR-1208) which can aberrant express in cancer or act as oncogenes or tumor suppressors16.