For example, ACADS and ACOX2 are involved in fatty acid metabolism33, 34; B3GALNT1, B4GALT7, HEXA and MAN1B1 are in glycan synthesis and metabolism35-38; other genes are categorized into ion transport (CNGA3 and SLC12A7)39, 40, NAD metabolism (NNMT, NQO2)41, 42, and redox and tyrosine metabolism (FAH)43, indicating that aberrant gene expressions in multiple metabolic pathways affect the prognosis of glioma. This evidence concerns the gene NNMT and central nervous system cancer.