TNKS and cancer: Many reports have shown that TNKS inhibition stabilizes AXIN and antagonizes Wnt/β-catenin signaling in various cancers, such as lung cancer 11, gastric cancer 12, 13, bladder cancer 14, astroglial brain tumor 15, pancreatic adenocarcinoma 16, breast cancer 17, bone cancer 18, and colon cancer 19, 20.