For example, overexpressed A1BG has been reported in both the blood level and tumor sections of lung cancer 34; High expression of APLN is shown to significantly stimulated tumor growth and micro vessel densities; RSPO3 aberrantly expressed at high levels showed to promotes tumor aggressiveness 35; ZNF185 is investigated to inhibit growth and invasion of lung adenocarcinoma cells through inhibition of the AKT /GSK3β pathway 36. The gene discussed is RSPO3; the disease is lung cancer.