The expression levels of TBX2 with the presence of bone metastasis showed four times more than the parental cells, showed in Supplementary Figure S4C. Additionally, profiling from Fong's cohort (GSE5123), which reported the gene expression associated with recurrence of lung cancer, implicated an obvious and significant upregulation in the recurrent group (p<0.05), showed in Supplementary Figure S4(D). This evidence concerns the gene TBX2 and lung cancer.