TRPV6 and familial pancreatic carcinoma: Using siRNA to knock down TRPV6 expression in the capan-2 cell line model of pancreatic cancer resulted in significant decrease in Bcl-2 (B-cell lymphoma 2, apoptosis inhibitor) and increase in BAX (Bcl-2-associated X protein, a promoter of apoptosis) which, taken together, indicate activation apoptosis 123.