Arora et al (21) reported the upregulation of RECQL5 in breast cancer due to gene amplification and described a critical role for RECQL5 in cancer progression and demonstrated that small interfering RNA-mediated knockdown of RECQL5 can significantly inhibit in vivo tumorigenicity and in vitro clonogenic survival of breast cancer cells (30). This evidence concerns the gene RECQL5 and breast carcinoma.