RUNX1 and leukemia: There was no significant difference in the KIT mutation frequency, but while KIT exon 8 frameshift mutations are associated with CBFB/MYH11-rearranged leukemia (n = 31), they are underrepresented in RUNX1/RUNX1T1 leukemia (n = 5) and here outnumbered by KIT D816 point mutations (n = 33 vs.10, 25%; Fig. 3).