FLT3-ITD mutations were less common in our cohort than in cytogenetic normal AML (13/162; 8%), whereas point mutations or short deletions in FLT3 (e.g. D835mut n = 18, N676K n = 8) had a frequency of 18% and were associated with the inv(16) subtype. Here, FLT3 is linked to acute myeloid leukemia.