Mutations in DHX15 and SMC1A correlated with shorter OS in RUNX1/RUNX1T1 leukemia (DHX15: HR = 3.57, p = 0.02; SMC1A: HR = 6.47, p < 0.001), while point mutations in KIT at position D816 correlated with reduced RFS in RUNX1/RUNX1T1 leukemia (HR = 2.27, p = 0.046; Supplementary Fig. S7). Here, RUNX1T1 is linked to leukemia.