In regards to recently published data on the prognostic impact of clonal interference in CBF leukemia [34], parallel evolution of more than one mutation in the signaling genes KIT, RAS, FLT3, JAK1/2, CBL, or PTPN11 in a single patient (assuming that these mutations arise in independent subclones) did not affect overall or RFS in our CBF leukemia cohort (Supplementary Figs. S5 and S6). Here, FLT3 is linked to leukemia.