They also developed IgG1+, IgG2a+, IgG2b+, and IgG3+B cells, CD138+IgG1+, CD138+IgG2a+, CD138+IgG2b+, and CD138+IgG3+ plasmablasts/plasma cells, skin lesions (MRL/Faslpr/lpr), IgG1/IgG2 kidney deposition and glomerular sclerosis. This evidence concerns the gene IGHG3 and Glomerular sclerosis.