However, compared with controls (Supplementary Fig. 5f, h), the numbers of GATA4-positive Leydig cells were reduced in 0.03% BC-treated testes (Supplementary Fig. 5g), and αSMA-positive PMCs were almost completely lost (Supplementary Fig. 5i), similar to our observations in 0.03% BC-treated mouse testis (Supplementary Fig. 1c). The gene discussed is ACTA1; the disease is breast cancer.