Consistent with the observations derived from the analysis of human SSTs, stable expression of tGLI2 and the FHL2-GLI2 fusion in MSC, HEK-293, DAOY, and BCC cells resulted in a significant increase in the expression levels of the SHH receptor PTCH1 and/or GLI1/CCND1 as compared to empty vector, wild-type FHL2 and wild-type GLI2 (Fig. 4c). This evidence concerns the gene GLI1 and skin basal cell carcinoma.