For example, adenoid cystic carcinomas of the breast are primarily driven by the MYB-NFIB fusion gene in ~80% of cases43,44; in breast adenoid cystic carcinomas lacking these fusions, MYBL1 rearrangements and MYB gene amplification have been reported as alternative mechanisms resulting in MYB overexpression and activation of MYB targets45. This evidence concerns the gene NFIB and adenoid cystic breast carcinoma.