Whilst we utilized DAOY and BCC cell lines given their dependence on the SHH pathway22,48,49, as expected in the setting of preexisting activation of GLI-signaling, the effects of FHL2-GLI2 expression in DAOY and BCC cell lines, albeit mostly significant, were not as overt as those observed in MSCs and HEK-293 cells. Here, SHH is linked to skin basal cell carcinoma.