IFNA1 and viral infectious disease: Furthermore, the type I IFN signaling pathway (GO:0060337) and cytoplasmic PRR signaling pathway in response to virus (GO:0039528) are among the pathways with the highest ratio of significantly differentially regulated genes to the total number of genes associated to the pathways, indicating the competence of PHH to sense viral infections and trigger IFN release and innate immune response (Fig. 7E).