In a study of skeletal muscle of people with a family history of T2D, Nitert et al. [41] found differentially methylated DNA in genes of certain pathways, including the mitogen-activated protein kinase (MAPK), insulin, and calcium signaling pathways (e.g., MAPK1, MYO18B, HOXC6, and PRKAB1). This evidence concerns the gene INS and type 2 diabetes mellitus.