Of note, the CREB Signaling in Neurons pathway was also significantly enriched in our ADHD–BMI gene-based meta-analysis, along with two other partially overlapping pathways involved in synaptic plasticity processes (namely, the Synaptic Long Term Depression and the Synaptic Long Term Potentiation pathways; Table 2), which are also closely related to dopamine DARPP-32 signaling. This evidence concerns the gene CREB1 and attention deficit-hyperactivity disorder.