SFTPB and acute respiratory distress syndrome: Moreover, the bronchoalveolar lavage fluid total protein was decreased with a substantial increase of surfactant protein B concentration and epithelial cadherin tissue expression.[39] In terms of VILI, Emr et al demonstrated that the APRV could prevent the VILI and ARDS comparing to the conventional MV and PEEP in healthy rats.[40] Besides, APRV has little effect on the cardiovascular system, which could improve heart function to some extent, restore or approaching normal V/Q ratio, increase systemic blood flow, and improve the perfusion of the whole body and organ.[41]