Thus, the use of intermittent colchicine only for the treatment of acute episodes of FMF is not recommended as it does not prevent the development of amyloidosis due to mild inflammation that can occur during asymptomatic periods.[11] TCZ inhibits IL-6, which is important in the pathogenesis of FMF, but does not eradicate FMF. This evidence concerns the gene IL6 and familial Mediterranean fever.