Familial Mediterranean fever (FMF) is the most common autoinflammatory disorder characterized by recurrent attacks of fever with arthritis, abdominal pain, skin rash, and/or serositis.[1,2] In clinical practice, the therapy for FMF is introduced to prevent febrile episodes and to normalize levels of acute-phase reactants, such as C-reactive protein (CRP). This evidence concerns the gene CRP and familial Mediterranean fever.