We observed the four core processes in the activation of WNT/β-catenin signaling pathway in the OA arthritis model, including the phosphorylation of GSK3β, the binding of Dvl to Frizzled protein, β-catenin enriched and transferred to nucleus, as well as the binding of β-catenin, TCF/LEF transcription factor and MMP promoters in nucleus. This evidence concerns the gene GSK3B and Arthritis.