The expression patterns of S100A4 were also evaluated by qRT-PCR in Doc-sensitive (n=6) vs Doc-resistant (n=6) tumor samples from clinical PCa patients [Supplementary Figure 1A] as well as the cells of DU145, DU145R, PC3 and PC3R [Supplementary Figure 1B and 1C]. Here, S100A4 is linked to posterior cortical atrophy.