Yang P. et al found that glioma tube growth could be suppressed with by circ-ZNF292 silencing, which can limit cell cycle progression at S/G2/M stage through the Wnt/β-catenin signaling pathway and gene regulations like PRR11, Cyclin A, p-CDK2, VEGFR-1/2, p-VEGFR-1/2 and EGFR [11]. The gene discussed is FLT1; the disease is central nervous system cancer.