Thus, it is plausible that Ubenimex inhibits autophagy in GC cells by suppressing the activity of PI3K and AKT, resulting in the impediment of IkB-α degradation and NF-κB phosphorylation, and the down-regulation of LC3B, Beclin-1, and ATG5, but increased expression of SQSTM1. This evidence concerns the gene ATG5 and gastric cancer.