AKT1 and gastric cancer: Emerging evidences have confirmed that autophagy induction [6, 7], the progress of epithelial-mesenchymal transition (EMT) [8, 9], and the overactivation of the phosphoinositol 3-kinase/protein kinase B (PI3K/AKT) pathway contribute to the development of CDDP resistance in GC [10, 11].