AKT1 and gastric cancer: Additionally, our findings affirmed that Ubenimex weakens the activation of the CD13/EMP3/ PI3K/AKT/NF-κB pathway to reverse CDDP resistance in GC, in which cell autophagy was inhibited, followed by an increase in CDDP-induced apoptosis, and EMT development was impeded, which was accompanied by the abatement of cell migration and invasion.