Factors univariately associated with shorter EFS were age at diagnosis >59 years (hazard ratio [HR] = 4.7; P = 0.038), osteoporosis (HR = 4.8; P = 0.043), advanced disease stage (HR = 16.9; P = 0.001), ALP≤110 (HR = 8; P = 0.031), total cholesterol ≤4.7 (HR = 7.7; P = 0.011), triacylglycerols (TAG)≤1.22 (HR = 11.8; P = 0.038), platelets ≤188 (HR = 13.4; P = 0.002), albumin <39 (HR = 9; P = 0.005), corticosteroid therapy (HR 5.8; P = 0.038), non-adherence to therapy (HR = 9.4; P = 0.017), and no response to therapy at 12 months (HR = 12; P = 0.001). The gene discussed is ALB; the disease is osteoporosis.