In our previous study, N-hydroxy-4-(2-methoxy-5-(methyl(2-methylquinazolin-4-yl)amino)phenoxy)butanamide (23BB, Supplementary Figure S1) as a highly selective HDAC6 inhibitor has been designed, synthesized and substantiated by anti-tumor activity in both solid and hematologic tumor models with good safety [18]. This evidence concerns the gene HDAC6 and neoplasm.