The arthritis scores of rats declined in the miR-101-3p mimics group, sh-PTGS2 group and miR-101-3p inhibitors + sh-PTGS2 group versus the mimic-NC group, sh-NC group, and the miR-101-3p inhibitors + sh-NC group, respectively (all P<0.05). The gene discussed is PTGS2; the disease is arthritic joint disease.