Relative to the miR-101-3p inhibitors + sh-NC group, the expression of miR-101-3p in RA-FLSs in the miR-101-3p inhibitors + sh-PTGS2 group was not significantly different (P>0.05), and the expression of PTGS2 was decreased (P<0.05). The gene discussed is PTGS2; the disease is rheumatoid arthritis.