Von Willebrand factor (VWF) is a large multimeric adhesive glycoprotein selectively produced in megakaryocytes (MKs) and endothelial cells (ECs).1 Patients with von Willebrand disease lack functional VWF protein and exhibit a moderate to severe hemorrhagic phenotype.2 Mature multimers of VWF are released into the blood from storage in Weibel‐Palade bodies in ECs and from α‐granules in activated platelets. This evidence concerns the gene VWF and Von Willebrand disease.