However, perhaps the most outstanding feature is the fact that PDEs contextually preserve the original architecture of the tissue, thus allowing assessment of responses to agents that target the TME.69,89 There has been a desperate search for models that allow the testing and stratification of ICIs, such as monoclonal antibodies that target PD-L1 or its receptor.16 These immunotherapies show unprecedented activity in a range of cancer types. The gene discussed is CD274; the disease is cancer.