Moreover, the inhibition of atherosclerosis by suppressing EGF signalling has been validated in different animal models.27, 28 In order to investigate whether nucleolin played a role in the phenotypic transformation of VSMCs by binding to the mRNA molecules of EGF and PDGF‐BB, regulated their stability and up‐regulated their expressions, we first observed the expressions of EGF and PDGF‐BB at the mRNA and protein levels in the phenotype transformation of VSMCs induced by Ang II. This evidence concerns the gene NUCLEOLIN and atherosclerosis.