Against the baseline of clinicopathological variables recommended in guidelines (like NCCN and ESMO), there is a potential value in assessing sidedness, pT3-subclassification, pN-subclassification, and postoperative CEA when discussing the value of administrating adjuvant chemotherapy and its duration in radically operated colon cancer patients1,2. The gene discussed is CEACAM5; the disease is colonic neoplasm.