The 21 women and 29 men with median age of 56.5 years (range 30–73) presented with T2 (10%), T3 (58%), or T4 (32%) disease, the majority (82%) with involved lymph nodes and tumor wild-type KRAS status (67% of the 39 analyzed cases; Table 1). The gene discussed is KRAS; the disease is neoplasm.