In particular, spheroidal tumor cell cultures have been demonstrated to exhibit a number of signaling pathway alterations such as changes in epidermal growth factor family, mitogen-activated protein kinase, and protein kinase B (AKT)-mammalian target of rapamycin (mTOR) signaling that can broadly influence tumor cell phenotype and drug sensitivities.110–112. Here, WNK2 is linked to neoplasm.