CACNA2D1 and Intellectual disability: In addition, loss-of-function mutations in some VGCCs are also reported, i.e., CACNA1H R212C, R902W, W962C, and A1874V reduce their activity in ASD [74]; CACNA2D1 is deleted in epilepsy and intellectual disability [74]; CACNG2 V143L decreases its binding to GLUR1 or GLUR2 [75]; and Cacng2 hypomorph results in epileptic phenotype [74].