Using total protein from HCC827 xenograft tumour tissues, we found that Afatinib inhibited the phosphorylation of JAK1,2, STAT3, and FAK, the protein expression of LYVE-1, VEGFR2, VEGFR3, VEGFC, VEGFA, and CCR7 (Figure 6D). Here, STAT3 is linked to neoplasm.