Among the 108 patients with tumor metastasis, 56 patients (51.8%) had high expression of both HIF-1α and SP1, 12 patients (11.1%) had high expression of HIF-1α, 13 patients (12.0%) had high expression of SP1, and 27 patients (25.0%) patients had low expression of both HIF-1α and SP1 (Figure 4g). The gene discussed is HIF1A; the disease is neoplasm.