However, the knockdown of STK24 induced the tumor growth of gastric cancer in vivo. Those results that implications for several possibilities (1) the accumulation of Ly6C+ cells of spleen were associated with tumor progression 26,27, (2) IL-6 expression of knockdown of STK24 cancer cells may be associated with macrophage polarization within the gut microenvironment 28, (3) G-CSF is produced by knockdown of STK24 cancer cells in the tumour microenvironment leading to tumour growth and progression 29. Here, IL6 is linked to gastric cancer.