CXCL16 is highly expressed in many cancers, including ovarian, breast, prostate, colon, and liver cancers, and the expression of CXCL16/CXCR6 correlates with lymph node metastasis in epithelial ovarian carcinoma 52,53. This evidence concerns the gene CXCR6 and metastatic malignant neoplasm in the lymph nodes.