CXCL16 is highly expressed in many cancers, including ovarian, breast, prostate, colon, and liver cancers, and the expression of CXCL16/CXCR6 correlates with lymph node metastasis in epithelial ovarian carcinoma 52,53. Here, CXCL16 is linked to metastatic malignant neoplasm in the lymph nodes.