Consistent to what has been mentioned previously 51, we found significant higher BCL6 gene abnormalities in non-GCB subtype (38%) than in GCB subtype (2%) (p=0.03), suggesting that the DLBCL GCB and non-GCB subtype have separate molecular mechanisms of DLBCL pathogenesis responsible for the abnormal protein expression. This evidence concerns the gene BCL6 and diffuse large B-cell lymphoma.