However, whether ALDH high activity is suitable as a marker to enrich DLBCL CSCs has not been reported, although the previous studies showed high expression of ALDH1A1, an isoform of ALDH, mediated chemo-resistance and associated with worse prognosis in DLBCL by immunohistochemistry 22-24. This evidence concerns the gene LDHA and diffuse large B-cell lymphoma.