Since the enzymatic activity of PLOD1, 2 and 3 has great impact on the component and structure of the ECM, and SHC1 was positively co-expressed with PLODs in GC, we therefore hypothesized that PLODs synergized with SHC1 and participated in integrin-SHC1 signaling cascades to regulate GC cell proliferation and migration by modifying the ECM (Supplementary Figure 3D). The gene discussed is SHC1; the disease is gastric cancer.