Anti-CTLA-4 mainly acts on the lymph node area, restores the induction and proliferation of activated T cells, and resists PD-1 acts mainly on the periphery of the tumor site, preventing the tumor-infiltrating tumor-infiltrating PD-L1-expressing tumor and plasma-like dendritic cells from neutralizing cytotoxic T cells 53. The gene discussed is PDCD1; the disease is neoplasm.