HUWE1 and neoplasm: Through much deeper analyzing 4437 genes which were located in the CNA regions (the frequency ≥10%), we explored and selected out 23 tumor suppressor genes located in CN loss regions (TADA3, VHL, PLCD1, CSRNP1, LZTFL1, LRRC2, NAT6, TUSC2, RASSF1, PCBP4, BAP1, ERC2-IT1, PTPRG, FOXP1, etc.), and 10 oncogenes (ABL2, RAB10, ADGRA3, BRAF, MET, LYN, MOS, RAB2A, RNF139, HUWE1) which were located in CN gain regions (Table 4).