In another study, it reported some high-frequency CNA regions and functional genes by whole-genome sequencing in 85 ccRCC samples, for example, EPM2AIP1 and SUSD5 at 3p22-p24, APEH, SETD2 and SMARCC at 13p21.31, SLC6A6 and VHL at 3p25, YLPM1 at 14q24.3, C14orf39 at 14q23, PNLIP at 10q25, DOCK2 at 5q35.1, KAT5 at 11q13.1, CHRNB2 and ECM1 at 1q21.2, AKAP9 and MUC17 at 7q11-q22 10. The gene discussed is ECM1; the disease is nonpapillary renal cell carcinoma.