TIMP1 and type 2 diabetes mellitus: These results suggest that poor control glycemic in T2DM patients generates increased levels of polymorphonuclear in the blood, but those cells lack the ability to defend against and the activity of MMP-2/TIMP-1, where TIMP-1 is more susceptible to a change in glycemic control in periodontal tissue, developing an unbalance in relating MMP-2/TIMP-1 to develop periodontitis [45, 46].