LGALS1 and colorectal carcinoma: Some research also showed that shikonin can be used as a chemotherapeutic drug cisplatin by activating intracellular oxidative stress.31-33 In the our study, we examined the antitumor effects of shikonin in CRC in vitro and in vivo and elucidated that shikonin induced the production of ROS and dimeration of galectin-1, which was found associated with the sensitivity of CRC cell lines to shikonin.