CXCL8 and colorectal carcinoma: Moreover, Faecalibacte praiumnitzii can also produce another anti-inflammatory metabolite, salicylic acid, which can significantly reduce IL-8 levels in vitro22.In conclusion, Faecalibacterium prausnitzii is an important anti-inflammatory microbiome known in the intestine, and more and more studies have linked it to CRC 23.In our study, the serum metabolite hydrocortisone (Cortisol) showed a significant positive correlation with Faecalibacterium Prausnitzii.