18, 19 EIF4E-BP1 is known to have important effect on mTOR signaling through translational control of key carcinogenic mRNA encoding proteins for cell cycle progression, cell survival, angiogenesis, cancer progression and metastasis. EIF4E-BP1 expression is regulated by transcriptional and post-translational mechanisms. 20-22 EIF4E-BP1 is an oncogene that is overexpressed in a wide range of cancers. 23. Here, EIF4E is linked to cancer.