The APAF1 gene is implicated in various pathophysiological pathways such as platinum drug resistance, apoptosis, and neurodegenerative diseases—e.g., Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, Huntington’s disease, legionellosis, tuberculosis, hepatitis B, and cancer (https://www.genome.jp/). This evidence concerns the gene APAF1 and amyotrophic lateral sclerosis.