NLRP3 and brain injury: In several other studies, MCC950 was found to efficiently repress the NLRP3 inflammasome induced by traumatic brain injury and decrease the neurological severity score in mice model of unilateral cortical impact, controlled cortical injury impact and isofluorane-induced traumatic brain injuries (Fan et al., 2018; Ismael et al., 2018; Xu et al., 2018).