CASP1 and early-onset autosomal dominant Alzheimer disease: VX-765 also called Belnacasan is an orally active form of VRT-043198 and although being promising in the eradication of Alzheimer’s disease manifestations, the necessity of continuous administration of VX-765 and treatment at very early stages of the disease, VX-765 seems to stay as a proof-of-concept of caspase-1’s implication in Alzheimer’s disease.