NLRP3 and ASC levels were upregulated and NLRP3, ASC, and cleaved caspase-1 colocalized with Iba the marker for activated glia in postmortem brain sections of PD patients as well as two mouse models of PD triggered by either 6-hydroxydopamine or α-synuclein performed fibril injections (Gordon et al., 2018). Here, NLRP3 is linked to Parkinson disease.