NLRP3 and Parkinson disease: Moreover, depletion of Nlrp3 protected from dopaminergic neuron loss, and decreased microglia recruitment and activation and resulted in a lower level of IL-1β in a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD (Lee et al., 2019).