CXCL1 and Alzheimer disease: To study how BLMH expression is affected by the chronic inflammatory environment in AD, we used the DiseaseLand transcriptomic database to perform a meta-analysis of 7 AD cohorts (Table 1) and discovered a reduction of BLMH gene expression correlated with increased CXCL8 and GROα in skin from AD patients compared to healthy individuals in the majority of the clinical studies (Fig. 1A).