CHI3L1 and prion disease: Furthermore, we confirmed previous evidence of a more pronounced elevation of YKL-40 in prion disease compared to AD and the lack of a difference in YKL-40 levels between FTD and AD [15, 18–21], which is also supported by the presence of comparable degrees of YKL-40 immunoreactivity in the brains with CBD, PSP, and AD [50].