In the prion disease group, the disease stage correlated with CHIT1 (Spearman’s rho = 0.287; p = 0.009), YKL-40 (Spearman’s rho = 0.366, p = 0.001), and t-tau (Spearman’s rho = 0.354, p = 0.001) values. The gene discussed is CHI3L1; the disease is prion disease.